Dimethylformamide dimethyl acetal → 3-(Dimethylamino)-1-[2-(trifluoromethyl)phenyl]prop-2-en-1-one

HRID 1707051Notes

Reaction equation

HRID 1707051 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9](=[O:11])[CH3:10].CO[CH:16](OC)[N:17]([CH3:19])[CH3:18]>>[CH3:16][N:17]([CH3:19])[CH:18]=[CH:10][C:9]([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:12])([F:13])[F:1])=[O:11]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 870952'-(Trifluoromethyl)acetophenone

Product 1

HCID 542598323-(Dimethylamino)-1-[2-(trifluoromethyl)phenyl]prop-2-en-1-one

Procedure

A mixture of 35 g. of o-trifluoromethylacetophenone in 35 ml. of dimethylformamide dimethylacetal is refluxed for 8 hours under anhydrous conditions and then evaporated to a yellow oil. Bulb to bulb distillation gives the desired product as a thick yellow oil.

Workup

  1. additionA mixture of 35 g
  2. customevaporated to a yellow oil
  3. distillationBulb to bulb distillation

Sources & evidence

ORD record
ord-3949ba02a8e34b0891de5e26171f141d
Source dataset
uspto-grants-1980_06
Patent number
US04209621

Reaction notes

Loading…