Magnesium orthosilicate → 1-(2-Chlorophenyl)-3-(dimethylamino)prop-2-en-1-one

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Reaction Steps

A mixture of 25 g. of o-chloroacetophenone and 25 ml. of dimethylformamide dimethylacetal is refluxed for 16 hours. Evaporation gives a thick red-brown oil which is dissolved in methylene chloride and this solution passed through a hydrous magnesium silicate column. Evaporation of solvent gives an oil which is then purified by bulb to bulb distillation.

Provenance & Evidence