Magnesium orthosilicate → 1-(2-Chlorophenyl)-3-(dimethylamino)prop-2-en-1-one

HRID 1707055Notes

Reaction equation

HRID 1707055 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9].CO[CH:13](OC)[N:14]([CH3:16])[CH3:15].[Si]([O-])([O-])([O-])[O-].[Mg+2].[Mg+2]>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH:9]=[CH:13][N:14]([CH3:16])[CH3:15]

Participants

5

Reactant 3

HCID 66225Magnesium orthosilicateHCID 72864Ethanone, 1-(2-chlorophenyl)-HCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 538407941-(2-Chlorophenyl)-3-(dimethylamino)prop-2-en-1-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 25 g. of o-chloroacetophenone and 25 ml. of dimethylformamide dimethylacetal is refluxed for 16 hours. Evaporation gives a thick red-brown oil which is dissolved in methylene chloride and this solution passed through a hydrous magnesium silicate column. Evaporation of solvent gives an oil which is then purified by bulb to bulb distillation.

Workup

  1. additionA mixture of 25 g
  2. customEvaporation
  3. customgives a thick red-brown oil which
  4. customEvaporation of solvent
  5. customgives an oil which
  6. distillationis then purified by bulb to bulb distillation

Sources & evidence

ORD record
ord-1228b0cf159c45249af43320a28bea3e
Source dataset
uspto-grants-1980_06
Patent number
US04209621

Reaction notes

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