3-Dimethylamino-3'-trifluoromethylacrylophenone → 7-[3-(Trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidine

HRID 1707060Notes

Reaction equation

HRID 1707060 reaction equation
[NH2:1][C:2]1[N:6]=[CH:5][NH:4][N:3]=1.CN(C)[CH:9]=[CH:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=1)=O>C(O)(=O)C>[F:20][C:19]([F:21])([F:22])[C:15]1[CH:14]=[C:13]([C:11]2[N:3]3[N:4]=[CH:5][N:6]=[C:2]3[N:1]=[CH:9][CH:10]=2)[CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenoneHCID 178418311HCID 178418311, compound

Product 1

HCID 203333607-[3-(Trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidine

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 3.36 g. of 3-amino-1,2,4-triazole and 9.66 g. of 3-dimethylamino-3'-trifluoromethylacrylophenone in 50 ml. of glacial acetic acid is refluxed for 5 hours. The resulting mixture is worked up as described in Example 54 to give the product of the Example, m.p. 158.5°-159.5° C.

Workup

  1. additionA mixture of 3.36 g
  2. customto give the product of the Example, m.p. 158.5°-159.5° C.

Sources & evidence

ORD record
ord-28fa5bcee52c4996a0fece6eb4ef1209
Source dataset
uspto-grants-1980_06
Patent number
US04209621

Reaction notes

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