HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Dimethylamino-3'-trifluoromethylacrylophenone → 7-[3-(Trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Dimethylamino-3'-trifluoromethylacrylophenone | HCID 730024 | — |
| Reactant | HCID 178418311 | HCID 178418311 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 7-[3-(Trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidine | HCID 20333360 | — |
Reaction Steps
A mixture of 3.36 g. of 3-amino-1,2,4-triazole and 9.66 g. of 3-dimethylamino-3'-trifluoromethylacrylophenone in 50 ml. of glacial acetic acid is refluxed for 5 hours. The resulting mixture is worked up as described in Example 54 to give the product of the Example, m.p. 158.5°-159.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04209621 |
| Source dataset | uspto-grants-1980_06 |
| ORD ID | ord-28fa5bcee52c4996a0fece6eb4ef1209 |
| Source note | uspto-grants-1980_06 |