3-Amino-5-methyl-4H-1,2,4-triazole → HCID 20333328, compound

HRID 1707061Notes

Reaction equation

HRID 1707061 reaction equation
[NH2:1][C:2]1[N:6]=[C:5]([CH3:7])[NH:4][N:3]=1.CN(C)[CH:10]=[CH:11][C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=1)=O>C(O)(=O)C>[CH3:7][C:5]1[N:6]=[C:2]2[N:1]=[CH:10][CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:21])([F:22])[F:23])[CH:15]=3)[N:3]2[N:4]=1

Participants

4

Reactant 2

HCID 2346103-Amino-5-methyl-4H-1,2,4-triazoleHCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenone

Product 1

HCID 20333328HCID 20333328, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 0.49 g. of 3-amino-5-methyl-1,2,4-triazole and 1.26 g. of 3-dimethylamino-3'-trifluoromethylacrylophenone in 25 ml. of glacial acetic acid refluxed for 16 hours. The resulting mixture is worked up as described in Example 54 to give the product of the Example, m.p. 153°-154° C.

Workup

  1. additionA mixture of 0.49 g
  2. customto give the product of the Example, m.p. 153°-154° C.

Sources & evidence

ORD record
ord-a6cebb3b2f984f8e9e9bc8a3894c4380
Source dataset
uspto-grants-1980_06
Patent number
US04209621

Reaction notes

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