HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Dimethylamino-3'-trifluoromethylacrylophenone → 2-Ethyl-7-(m-trifluoromethylphenyl)-1,2,4-triazolo[1,5-a]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Dimethylamino-3'-trifluoromethylacrylophenone | HCID 730024 | — |
| Reactant | 5-ethyl-1H-1,2,4-triazol-3-amine | HCID 1714204 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Ethyl-7-(m-trifluoromethylphenyl)-1,2,4-triazolo[1,5-a]pyrimidine | HCID 20333365 | — |
Reaction Steps
A mixture of 2.24 g. of 3-amino-5-ethyl-1,2,4-triazole and 4.86 g. of 3-dimethylamino-3'-trifluoromethylacrylophenone in 50 ml. of glacial acetic acid is refluxed for 16 hours. The resulting mixture is worked up as described in Example 54 to give the product of the Example, m.p. 132°-134° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04209621 |
| Source dataset | uspto-grants-1980_06 |
| ORD ID | ord-5aee4fedb5c848efb47806bdadc4cb0f |
| Source note | uspto-grants-1980_06 |