3-(Dimethylamino)-1-[2-(trifluoromethyl)phenyl]prop-2-en-1-one → HCID 20333363, compound

HRID 1707063Notes

Reaction equation

HRID 1707063 reaction equation
[NH2:1][C:2]1[N:6]=[CH:5][NH:4][N:3]=1.CN(C)[CH:9]=[CH:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19]([F:22])([F:21])[F:20])=O>C(O)(=O)C>[F:20][C:19]([F:21])([F:22])[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[C:11]1[N:3]2[N:4]=[CH:5][N:6]=[C:2]2[N:1]=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 542598323-(Dimethylamino)-1-[2-(trifluoromethyl)phenyl]prop-2-en-1-oneHCID 178418311HCID 178418311, compound

Product 1

HCID 20333363HCID 20333363, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 1.68 g. of 3-amino-1,2,4-triazole and 4.86 g. of 3-dimethylamino-2'-trifluoromethylacrylophenone in 25 ml. of glacial acetic acid refluxed for 16 hours. The resulting mixture is worked up as described in Example 54 to yield the product of the Example, m.p. 149°-151° C.

Workup

  1. additionA mixture of 1.68 g
  2. customto yield the product of the Example, m.p. 149°-151° C.

Sources & evidence

ORD record
ord-446dce4980d1430f82490e44e3e0eb0a
Source dataset
uspto-grants-1980_06
Patent number
US04209621

Reaction notes

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