Methane → HCID 178506145, compound

Participants

Reaction Steps

A mixture of 12.2 g. of 3-dimethylamino-3'-trifluoromethylacrylophenone and 15.2 g. of thiourea is heated at 180°-190° C. for 2 hours. The cooled crude reaction mixture is dissolved in 200 ml. of 1 N sodium hydroxide solution and is treated with activated charcoal and filtered. The filtered solution is acidified with 1 N hydrochloric acid and the desired compound is collected by filtration, m.p. 200°-205° C.

Provenance & Evidence