Methane → HCID 178506145, compound

HRID 1707068Notes

Reaction equation

HRID 1707068 reaction equation
CN(C)[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)=O.[NH2:18][C:19]([NH2:21])=[S:20].[OH-].[Na+].C>>[SH:20][C:19]1[N:21]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:14])([F:15])[F:16])[CH:8]=2)[CH:4]=[CH:3][N:18]=1

Participants

5

Reactant 4

HCID 297MethaneHCID 14798Sodium HydroxideHCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenoneHCID 2723790Thiourea

Product 1

HCID 178506145HCID 178506145, compound

Procedure

A mixture of 12.2 g. of 3-dimethylamino-3'-trifluoromethylacrylophenone and 15.2 g. of thiourea is heated at 180°-190° C. for 2 hours. The cooled crude reaction mixture is dissolved in 200 ml. of 1 N sodium hydroxide solution and is treated with activated charcoal and filtered. The filtered solution is acidified with 1 N hydrochloric acid and the desired compound is collected by filtration, m.p. 200°-205° C.

Workup

  1. additionA mixture of 12.2 g
  2. temperatureThe cooled crude
  3. customreaction mixture
  4. dissolutionis dissolved in 200 ml
  5. filtrationfiltered
  6. filtrationthe desired compound is collected by filtration, m.p. 200°-205° C.

Sources & evidence

ORD record
ord-8660ebc37c1e4b28bf244e7a84b20bd0
Source dataset
uspto-grants-1980_06
Patent number
US04209621

Reaction notes

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