Methyl iodide → HCID 20333327, compound

HRID 1707070Notes

Reaction equation

HRID 1707070 reaction equation
[SH:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[CH:5]=[CH:4][N:3]=1.[OH-].[Na+].[CH3:20]I>>[CH3:20][S:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:15])[F:16])[CH:9]=2)[CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 178506145HCID 178506145, compound

Product 1

HCID 20333327HCID 20333327, compound

Procedure

A solution of 4.75 g. of 2-mercapto-4-(m-trifluoromethylphenyl)pyrimidine in 50 ml. of 1 N sodium hydroxide is cooled to near 0° C. in an ice bath and 2.90 g. of methyliodide is added. After the reaction mixture is allowed to warm to room temperature, the product is removed by filtration, m.p. 89°-90° C.

Workup

  1. customthe product is removed by filtration, m.p. 89°-90° C.

Sources & evidence

ORD record
ord-98a3e24346a743f692a31882b67163be
Source dataset
uspto-grants-1980_06
Patent number
US04209621

Reaction notes

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