2-(Bromomethyl)-1,4-difluorobenzene → HCID 178505811, compound

HRID 1707256Notes

Reaction equation

HRID 1707256 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C@H:10]3[CH2:15][CH2:14][C@H:13]([N:16]4[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]4)[CH2:12][CH2:11]3)=[CH:9][C:4]=2[O:3][CH2:2]1.[F:22][C:23]1[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:24]=1[CH2:25]Br>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C@H:10]3[CH2:15][CH2:14][C@H:13]([N:16]4[CH2:21][CH2:20][N:19]([CH2:25][C:24]5[CH:27]=[C:28]([F:31])[CH:29]=[CH:30][C:23]=5[F:22])[CH2:18][CH2:17]4)[CH2:12][CH2:11]3)=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 5228302-(Bromomethyl)-1,4-difluorobenzeneHCID 178420444HCID 178420444, compound

Product 1

HCID 178505811HCID 178505811, compound

Procedure

The title compound was prepared from trans 1-[4-(1,3-benzodioxol-5-yl) -1-cyclohexyl]piperazine and 2,5-difluorobenzyl bromide by the method described in example 15 to give the product (59%, top: 110°-111° C.). Calc'd for C24H28F2N2O2 : C, 69.55%; H, 6.81%; N, 6.76%. Found: C, 69.55%; H, 6.74%; N, 6.63%.

Workup

  1. customto give the product (59%, top: 110°-111° C.)

Sources & evidence

ORD record
ord-fd1c1b3008c84493aeab57ebeaa267ac
Source dataset
uspto-grants-1994_10
Patent number
US05352678

Reaction notes

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