Sodium Iodide → HCID 10332582, compound

HRID 1707428Notes

Reaction equation

HRID 1707428 reaction equation
Cl[CH2:2][S:3][C:4]1[N:8]=[CH:7][N:6]([CH3:9])[N:5]=1.[I-:10].[Na+]>CC(C)=O.O>[I:10][CH2:2][S:3][C:4]1[N:8]=[CH:7][N:6]([CH3:9])[N:5]=1

Participants

5

Reactant 2

HCID 5238Sodium IodideHCID 10419514HCID 10419514, compound

Product 1

HCID 10332582HCID 10332582, compoundYield 98%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of 3-chloromethylthio-1-methyl-1,2,4-triazole (981 mg: 6.0 mMol.) in acetone (10 ml) is added sodium iodide (1.78 g: 12 mMol.), and the mixture is stirred at 50° C. for 3 hours. The reaction mixture is diluted with water and extracted with ethyl acetate. The extract is washed with water, dried over sodium sulfate, and concentrated to give 3-iodomethylthio-1-methyl-1,2,4-triazole (1.50 g) as yellow oil.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe extract is washed with water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-03a5ec68243748339fa7bd95c5a1bc9e
Source dataset
uspto-grants-1994_10
Patent number
US05352792

Reaction notes

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