反应详情

167 g (0.88 mol) of SnCl2 was added to 880 cm3 of diethyl ether, and dried HCl gas was absorbed to saturation at room temperature. 98 g (0.44 mol) of 4-bromo-3,5-difluorobenzonitrile was added all at once to this mixture, and after stirring for i hour, it was let stand overnight. The reactant was poured into 1,000 cm3 of water, and ether was distilled on a hot water bath at 50° C. The residue was extracted by adding chloroform, and after washing in water the chloroform was removed. The residue was distilled under reduced pressure (b. p. 96° C./73 mmHg) to obtain 88 g (0.40 mol) of 4-bromo-3,5-difluorobenzaldehyde.

1. customwas absorbed
2. customto saturation at room temperature
3. distillationwas distilled on a hot water bath at 50° C
4. extractionThe residue was extracted
5. additionby adding chloroform
6. washafter washing in water the chloroform
7. customwas removed
8. distillationThe residue was distilled under reduced pressure (b. p. 96° C./73 mmHg)