1-Ethylpiperazine → HCID 18961720, compound

HRID 1707573Notes

Reaction equation

HRID 1707573 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)[CH3:2].C(O[C:12]1[C:13](=[O:20])[C:14](=[O:19])[C:15]=1[O:16][CH2:17][CH3:18])C>CCOCC>[CH2:17]([O:16][C:15]1[C:14](=[O:19])[C:13](=[O:20])[C:12]=1[N:6]1[CH2:7][CH2:8][N:3]([CH2:1][CH3:2])[CH2:4][CH2:5]1)[CH3:18]

Participants

4

Reactant 2

HCID 791961-EthylpiperazineHCID 123228Diethyl squarate

Product 1

HCID 18961720HCID 18961720, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of N-ethylpiperazine (1.529 g) and 3,4-diethoxy-3-cyclobutene-1,2-dione (2.29 g) in ether (40 mL) was stirred at ambient temperature for 16 hours. The precipitated solid was collected by filtration to obtain the title compound (1.5 g) as a white solid. This material was used in Example 2 without further purification.

Workup

  1. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-a3938c264e754fc78c4e3a4bab756eba
Source dataset
uspto-grants-1994_10
Patent number
US05354746

Reaction notes

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