反应详情

温度

0 °C

4-Fluorophenyl isocyanate (0.74 mL, 6.51 mmol) is added to a mixture of 3-amino-4(3H)quinazolinone (1.00 g, 6.21 mmol) in 1,2-dichloroethane at reflux. The reaction mixture is heated at reflux for 18 hours, cooled to 0° C. and filtered. The filter cake is washed with ether and dried to give the title product as a white solid, 1.64 g (89%), mp 237°-238° C.

1. temperatureat reflux
2. temperatureThe reaction mixture is heated
3. temperatureat reflux for 18 hours
4. filtrationfiltered
5. washThe filter cake is washed with ether
6. customdried