反应详情

4-Bromophenyl isothiocyanate (2.51 g, 11.72 mmol) is added to a mixture of 3-amino-4(3H)quinazolinone (1.72 g, 10.66 mmol) in 1,2-dichloroethane at reflux under a nitrogen atmosphere. The reaction mixture is heated at reflux for 2 days, cooled, washed with ether and filtered. The filter cake is dried to give the title product as a white solid, 2.44 g, mp 189°-190° C.

1. temperatureat reflux under a nitrogen atmosphere
2. temperatureThe reaction mixture is heated
3. temperatureat reflux for 2 days
4. temperaturecooled
5. washwashed with ether
6. filtrationfiltered
7. customThe filter cake is dried