HCID 15224911, compound → HCID 131718730, compound

HRID 1707633Notes

Reaction equation

HRID 1707633 reaction equation
[Cl:1][C:2]1[CH:32]=[CH:31][C:5]2[O:6][C:7]3[CH:30]=[CH:29][CH:28]=[CH:27][C:8]=3[CH2:9][N:10]([C:11]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[O:12])[C:4]=2[CH:3]=1.Cl.O1CCOCC1>CO>[ClH:1].[Cl:1][C:2]1[CH:32]=[CH:31][C:5]2[O:6][C:7]3[CH:30]=[CH:29][CH:28]=[CH:27][C:8]=3[CH2:9][N:10]([C:11]([N:13]3[CH2:14][CH2:15][N:16]([C:19]([C:21]4[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=4)=[O:20])[CH2:17][CH2:18]3)=[O:12])[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 15224911HCID 15224911, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 131718730HCID 131718730, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title product of Example 28 was dissolved in 10 mL of MeOH. Excess 6.9N HCl/dioxane was added to the solution. After stirring this solution for 30 minutes, all solvent was removed under reduced pressure. The residue was dissolved in water/MeOH and lyophilized to produce 0.11 g of the title product as a granular white solid.

Workup

  1. customall solvent was removed under reduced pressure
  2. dissolutionThe residue was dissolved in water/MeOH

Sources & evidence

ORD record
ord-309046011f054db29182a04d8efcc9c3
Source dataset
uspto-grants-1994_10
Patent number
US05354747

Reaction notes

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