1-((Pyrrolidine-1-carbonyl)methyl)piperazine → HCID 15224922, compound

HRID 1707641Notes

Reaction equation

HRID 1707641 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11](Cl)=[O:12])[C:4]=2[CH:3]=1.[CH2:20]1[CH2:24][N:23]([C:25]([CH2:27][N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[O:26])[CH2:22][CH2:21]1>>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11]([N:31]3[CH2:30][CH2:29][N:28]([CH2:27][C:25]([N:23]4[CH2:22][CH2:21][CH2:20][CH2:24]4)=[O:26])[CH2:33][CH2:32]3)=[O:12])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 1006141-((Pyrrolidine-1-carbonyl)methyl)piperazineHCID 149759838-chlorodibenz[b,f][1,4]oxazepin-10(11H)carbonyl chloride

Product 1

HCID 15224922HCID 15224922, compoundYield 93.1%

Procedure

The title compound of Example 2 (0.75 g, 2.55 mmol) was reacted with 1-(1-piperazinylacetyl) pyrrolidine (0.50 g, 2.55 mmol) by the method of Example 4. Following chromatographic separation, 1.08 g of clear oil title product was obtained.

Workup

  1. customseparation

Sources & evidence

ORD record
ord-a7bc21bf9b7f449a8beeed6504dcbbe5
Source dataset
uspto-grants-1994_10
Patent number
US05354747

Reaction notes

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