Benzofuran-2-carboxylic acid → 2-Benzofurancarbonyl chloride

HRID 1707660Notes

Reaction equation

HRID 1707660 reaction equation
S(Cl)([Cl:3])=O.[O:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH:7]=[C:6]1[C:14]([OH:16])=O>C1C=CC=CC=1>[O:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH:7]=[C:6]1[C:14]([Cl:3])=[O:16]

Participants

4

Reactant 2

HCID 10331Benzofuran-2-carboxylic acidHCID 24386Thionyl Chloride

Product 1

HCID 389492-Benzofurancarbonyl chloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Thionyl chloride (12.5 ml) was added to a suspension of benzofuran-2-carboxylic acid (20 g) in anhydrous benzene (250 ml). The mixture was refluxed for 3 hours, then allowed to cool down to room temperature. Removal of the volatiles left the desired acid chloride (21.8g, 98%).

Workup

  1. temperatureThe mixture was refluxed for 3 hours
  2. customRemoval of the volatiles
  3. waitleft the desired acid chloride (21.8g, 98%)

Sources & evidence

ORD record
ord-df19e24fd19e4998ad22ca33642f0cd6
Source dataset
uspto-grants-1994_10
Patent number
US05354769

Reaction notes

Loading…