Hydrochloric Acid → 2-Chloro-4'-fluoroacetophenone

Temperature

80 °C

164 ml. (235.1 g., 2.04 moles) of chloroacetyl chloride is added over a 50 min. period to a mixture of 400 ml. (410 g., 4.22 moles) of fluorobenzene and 300 g. (2.25 moles) of anhydrous aluminum chloride stirred at 75° C. under nitrogen. The reaction mixture is stirred at 80° C. under nitrogen for 1 hour, cooled to 50° C., 500 ml. of fluorobenzene is added, and the reaction mixture is cooled to 0° C. and gradually (over a 30 min. period) siphoned into 1 l. of 6N. hydrochloric acid stirred at 0° C. (The temperature of the aqueous acid is maintained at or below 25° C. throughout the addition.) The quenched, acidified reaction mixture is stirred for 15 min., and the aqueous phase is separated and extracted with 350 ml. of fluorobenzene. The two organic phases are combined and washed twice with 500 ml. portions of 3N. hydrochloric acid and once with 500 ml. of water. The fluorobenzene is distilled at 30 mm. Hg. and 60° C. and, upon cooling, the obtained oily residue solidifies. The crude solid product need not be purified.

1. temperaturecooled to 50° C.
2. temperaturethe reaction mixture is cooled to 0° C.
3. waitgradually (over a 30 min. period) siphoned into 1 l
4. temperatureis maintained at or below 25° C.
5. additionthroughout the addition
6. customreaction mixture
7. stirringis stirred for 15 min.
8. customthe aqueous phase is separated
9. extractionextracted with 350 ml
10. washwashed twice with 500 ml
11. distillationThe fluorobenzene is distilled at 30 mm. Hg
12. temperatureand 60° C. and, upon cooling
13. customThe crude solid product need not be purified

ORD record

ord-220daadafbdd4b66800e371ecf12b17e

Source dataset

uspto-grants-1994_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05354772