Acetic Anhydride → HCID 178418641, Verbindung

HRID 1707721Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1707721
[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:23](=[NH:26])[NH:24][OH:25])=[CH:13][CH:12]=2)[C:8]2[C:27]([C:31]([O:33][CH3:34])=[O:32])=[CH:28][CH:29]=[CH:30][C:7]=2[N:6]=1)[CH2:2][CH2:3][CH3:4].C(N(CC)CC)C.[C:42](OC(=O)C)(=[O:44])[CH3:43]>ClCCl>[C:42]([O:25][NH:24][C:23]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[C:14]1[CH:15]=[CH:16][C:11]([CH2:10][N:9]2[C:8]3[C:27]([C:31]([O:33][CH3:34])=[O:32])=[CH:28][CH:29]=[CH:30][C:7]=3[N:6]=[C:5]2[CH2:1][CH2:2][CH2:3][CH3:4])=[CH:12][CH:13]=1)=[NH:26])(=[O:44])[CH3:43]

Komponenten

5

Edukt 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 178441474HCID 178441474, Verbindung

Produkt 1

HCID 178418641HCID 178418641, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of methyl 2-butyl-l-[[2'-(hydroxycarbamimidoyl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate (1.83 g) in dichloromethane (20 ml) was added triethylamine (0.46 g) and acetic anhydride (0.46 g), and the reaction mixture was stirred at room temperature for 2 hours. After evaporation of the solvent, the residue was partitioned between ethylacetate and water and the organic layer was washed with an aqueous solution of NaHCO3 and water. The solution was dried and concentrated to dryness to give a pale yellow solid (1.99 g, quant.)

Aufarbeitung

  1. customAfter evaporation of the solvent
  2. customthe residue was partitioned between ethylacetate and water
  3. washthe organic layer was washed with an aqueous solution of NaHCO3 and water
  4. customThe solution was dried
  5. concentrationconcentrated to dryness
  6. customto give a pale yellow solid (1.99 g, quant.)

Quellen und Nachweise

ORD-Eintrag
ord-0788dfc7289b47328cca28fafdf96eda
Quelldatensatz
uspto-grants-1994_10
Patentnummer
US05354766

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