反应详情

温度

40 °C

1 mole (229 g) of 3-benzyloxy-6-methoxyaniline is added to 700 ml of dimethylformamide and 0.5 mole (76 g) of 2-bromobutanone. The reaction medium is heated to 40° C. for 2 hours 30 minutes and then to 120° C. for three quarters of an hour. By adding ice and then cooling, an oil is obtained which is decanted and then dissolved in ethyl acetate. After washing with a 2N solution of hydrochloric acid, then with water and evaporation of the ethyl acetate, the desired product is obtained in the form of a dry extract which is recrystallized from cyclohexane under reflux. The desired product melts at 100° C.

1. customto 120° C.
2. customfor three quarters of an hour
3. additionBy adding ice
4. temperaturecooling
5. customan oil is obtained which
6. customis decanted
7. dissolutiondissolved in ethyl acetate
8. washAfter washing with a 2N solution of hydrochloric acid
9. customwith water and evaporation of the ethyl acetate