反应详情

To a solution of (R)-7-(4-fluorophenyl)-7-(3-formyl-6-hydroxy-2,4,5-trimethylphenyl)heptanoic acid (0.43 g, 1.1 mmol) in tetrahydrofuran (7 ml) was added, under ice-cooling, sodium borohydride (21.0 mg). The mixture was stirred for two hours at room temperature, to which was added acetone, then the solvent was distilled off under reduced pressure. The residue was neutralized with 1N HCl, which was subjected to extraction with ethyl acetate. The organic layer was washed with water and a saturated aqueous saline solution, followed by drying over magnesium sulfate. The solvent was distilled off under reduced pressure to leave 0.38 g of (R)-7-(4-fluorophenyl)-7-(2-hydroxy-5-hydroxylmethyl-3,4,6-trimethylphenyl)heptanoic acid, whose spectral data are shown in [Table 4].

1. temperaturecooling
2. distillationthe solvent was distilled off under reduced pressure
3. extractionwas subjected to extraction with ethyl acetate
4. washThe organic layer was washed with water
5. dry with materialby drying over magnesium sulfate
6. distillationThe solvent was distilled off under reduced pressure