Methanol → Gsk-8062

HRID 170802Notes

Reaction equation

[CH3:1][OH:2].[Cl:5][c:6]1[c:7](-[c:13]2[n:14][o:15][c:16]([CH:40]([CH3:41])[CH3:42])[c:17]2[CH2:18][O:19][c:20]2[cH:21][cH:22][c:23](-[c:26]3[cH:27][c:28]4[cH:29][cH:30][cH:31][c:32]([C:36](=[O:37])[O:38][CH3:39])[c:33]4[cH:34][cH:35]3)[cH:24][cH:25]2)[c:8]([Cl:12])[cH:9][cH:10][cH:11]1.[Na+:4].[O:43]1[CH2:44][CH2:45][CH2:46][CH2:47]1.[OH-:3]>>[Cl:5][c:6]1[c:7](-[c:13]2[n:14][o:15][c:16]([CH:40]([CH3:41])[CH3:42])[c:17]2[CH2:18][O:19][c:20]2[cH:21][cH:22][c:23](-[c:26]3[cH:27][c:28]4[cH:29][cH:30][cH:31][c:32]([C:36](=[O:37])[OH:38])[c:33]4[cH:34][cH:35]3)[cH:24][cH:25]2)[c:8]([Cl:12])[cH:9][cH:10][cH:11]1

Participants

Reactant 5

HCID 887Methanol

HCID 923Sodium ion

HCID 961Hydroxide

HCID 8028Tetrahydrofuran

HCID 59264878Methyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-naphthalenecarboxylate

Product 1

HCID 16214849Gsk-8062

Sources & evidence

ORD record: ord-273443d366204fcfac2651e06eb26193
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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