反应详情

To a suspension of 2-(4-fluorophenyl)-3-(pyridin-4-yl)- 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (250 mg) in ethanol (3.5 ml) was added 1N hydrochloric acid (0.85 ml). The resulting clear solution was concentrated in vacuo. To the residue was added ethanol (1 ml) and the solution was concentrated in vacuo. The residue was crystallized from a mixture of methanol (0.5 ml) and ethyl acetate (3 ml) and recrystallized from an aqueous isopropyl alcohol solution to give 2-(4-fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine hydrochloride (233 mg).

1. concentrationThe resulting clear solution was concentrated in vacuo
2. additionTo the residue was added ethanol (1 ml)
3. concentrationthe solution was concentrated in vacuo
4. customThe residue was crystallized from a mixture of methanol (0.5 ml) and ethyl acetate (3 ml)
5. customrecrystallized from an aqueous isopropyl alcohol solution