Hydrogen Bromide → 3-(3-Bromopropyl)pyridine

HRID 1708042Notes

Reaction equation

HRID 1708042 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9]O)[CH:2]=1.[BrH:11]>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9][Br:11])[CH:2]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 178613-Pyridinepropanol

Product 1

HCID 127015683-(3-Bromopropyl)pyridine

Procedure

To 17.0 g (124 mmoles) of 3-(3-pyridyl)-1-propanol was added 240 mL of 48% hydrobromic acid. The mixture was heated under reflux for 4 hours, and then evaporated to dryness to afford the hydrobromide salt of 3-(3-pyridyl)-1-bromopropane as an oil in quantitative yield.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 4 hours
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-643d83d8a99243dab44f684128ec68eb
Source dataset
uspto-grants-1994_10
Patent number
US05356906

Reaction notes

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