Phenyl chloroformate → HCID 54310263, compound

HRID 1708112Notes

Reaction equation

HRID 1708112 reaction equation
[CH3:1][O:2][N:3]=[C:4]([C:7]1[CH2:8][NH:9][CH2:10][CH2:11][CH:12]=1)[C:5]#[N:6].Cl[C:14]([O:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:15]>>[CH3:1][O:2][N:3]=[C:4]([C:7]1[CH2:8][N:9]([C:14]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:15])[CH2:10][CH2:11][CH:12]=1)[C:5]#[N:6]

Participants

3

Reactant 2

HCID 15891Phenyl chloroformateHCID 54399635HCID 54399635, compound

Product 1

HCID 54310263HCID 54310263, compoundYield 81.8%

Procedure

α-(Methoxyimino)-α-(1,2,5,6-tetrahydropyridin-3-yl)acetonitrile (D8) (0.5 g, 0.003 moles) was treated with phenyl chloroformate (0.42 ml, 0.0033 moles) according to the method of Example 1. The crude product was crystallised from diethyl ether/pentane to give the title compound (E3) as a white crystalline solid (0.7 g, 81%) m.p. 111°-112° C.

Workup

  1. customThe crude product was crystallised from diethyl ether/pentane

Sources & evidence

ORD record
ord-809cb784cc2542ab811cb1e92a0868fe
Source dataset
uspto-grants-1994_10
Patent number
US05356914

Reaction notes

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