1-Bromopropane → N-(3-Fluoro-4-pyridinyl)-2-methyl-N-propyl-1H-indol-1-amine

HRID 1708137Notes

Reaction equation

[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[NH:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[C:10]1[CH3:18].Br[CH2:20][CH2:21][CH3:22].[H-].[Na+]>>[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[N:8]([CH2:20][CH2:21][CH3:22])[N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[C:10]1[CH3:18]

Participants

Reactant 3

HCID 78401-Bromopropane

HCID 24758Sodium hydride

HCID 14988279N-(3-Fluoro-4-pyridinyl)-2-methyl-1H-indol-1-amine

Product 1

HCID 14988289N-(3-Fluoro-4-pyridinyl)-2-methyl-N-propyl-1H-indol-1-amine

Procedure

The title compound was prepared from N-(3-fluoro-4-pyridinyl)-2-methyl-1H-indol-1-amine and 1-bromopropane with the aid of NaH in substantially the same manner as in Example 4, m.p. 5° C.

Sources & evidence

ORD record: ord-3761baadc0f545f495e409c9468e1088
Source dataset: uspto-grants-1994_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05356910

Reaction notes

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