Ethanol → HCID 23352092, compound

HRID 1708150Notes

Reaction equation

HRID 1708150 reaction equation
O=[C:2]([CH2:9][C:10](=O)[CH2:11][CH2:12][CH2:13]C)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].[C:16]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])#[N:17].C(N(CC)CC)C.C([OH:33])C>>[CH2:10]([C:9]1[NH:17][C:16](=[O:33])[C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH:2]=1)[CH2:11][CH2:12][CH3:13]

Participants

5

Reactant 4

HCID 702EthanolHCID 7764Ethyl cyanoacetateHCID 8471TriethylamineHCID 18431641HCID 18431641, compound

Product 1

HCID 23352092HCID 23352092, compound

Procedure

10 g (50 mmol) of ethyl 2,4-dioxo-octanecarboxylate, 5.65 g (50 mmol) of ethyl cyanoacetate and 5 g (50 mmol) of triethylamine are heated under reflux overnight in 100 ml of ethanol.

Sources & evidence

ORD record
ord-875f07b57e794c20aab306e9fdd2f8f6
Source dataset
uspto-grants-1994_10
Patent number
US05356911

Reaction notes

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