HCID 15100222, compound → HCID 15100223, compound

HRID 1708159Notes

Reaction equation

HRID 1708159 reaction equation
[CH3:1][N:2]1[C:6]([S:7]([OH:10])(=[O:9])=[O:8])=[C:5](Cl)[N:4]=[CH:3]1.[H][H]>O.[Pd]>[CH3:1][N:2]1[C:6]([S:7]([OH:10])(=[O:9])=[O:8])=[CH:5][N:4]=[CH:3]1

Participants

5

Reactant 2

HCID 15100222HCID 15100222, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15100223HCID 15100223, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

A solution of 3.1 g (17 mmol) of 1-methyl-4-chloro-5-imidazolesulfonic acid from Example 5 in 100 ml of water is hydrogenated to constant pressure at 25° C. in the presence of 0.5 g of Pd/C catalyst with shaking at an initial pressure of 3.45 bar of hydrogen. The crystalline residue remaining after filtering off the catalyst and evaporating the water in vacuo is recrystallized from ethanol in order to give the title compound of melting point 286°-287° C.

Workup

  1. filtrationafter filtering off the catalyst
  2. customevaporating the water in vacuo
  3. customis recrystallized from ethanol in order

Sources & evidence

ORD record
ord-c6d1be13aac1486e9d55c8d6c8d88bbe
Source dataset
uspto-grants-1994_10
Patent number
US05356922

Reaction notes

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