反应详情

温度

80 °C

4.7 g (0.05 mol) of chloroacetic acid is added to a solution of 9.11 g (0.05 mol) of 4-hydroxy-3-methylmandelic acid and 6.0 g (0.15 mol) of sodium hydroxide in 25 ml of water, and the mixture is then stirred at 80° C. for 3 hours. The reaction mixture is acidified with concentrated hydrochloric acid, cooled with ice/water, and the precipitated product is filtered, washed with water and dried in a high vacuum, giving 5.65 g (62%) of 4-carboxymethoxy-3-methylmandelic acid, melting point 95°-100° C.

1. filtrationthe precipitated product is filtered
2. washwashed with water
3. customdried in a high vacuum