Hydrochloric Acid → HCID 19030802, compound

HRID 1708291Notes

Reaction equation

HRID 1708291 reaction equation
[C:1]([C:3]1[CH:27]=[CH:26][C:6]([C:7]([N:9]2[CH2:14][CH2:13][CH:12]([N:15]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH2:19][CH2:18][C:16]3=[O:17])[CH2:11][CH2:10]2)=[O:8])=[CH:5][CH:4]=1)#[N:2].[CH2:28]([OH:30])[CH3:29].Cl>C(Cl)(Cl)Cl>[CH2:28]([O:30][C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:7]([N:9]2[CH2:10][CH2:11][CH:12]([N:15]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH2:19][CH2:18][C:16]3=[O:17])[CH2:13][CH2:14]2)=[O:8])=[CH:26][CH:27]=1)=[NH:2])[CH3:29]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14969532HCID 14969532, compound

Product 1

HCID 19030802HCID 19030802, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

1-[1-(4-Cyanobenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril (1 g) is dissolved in chloroform (10 ml) and thereto is added ethanol (0.18 ml). Under ice cooling, hydrochloric acid gas is passed through the mixture to saturate and further the mixture is stirred at 5°-7° C. for 4 days. After the reaction, the solvent is concentrated to give 1-{1-[4-(1-ethoxy-1-iminomethyl)benzoyl]-4-piperidinyl}-3,4-dihydrocarbostyril (1 g). The product is used for the subsequent reaction.

Workup

  1. concentrationto saturate
  2. customAfter the reaction
  3. concentrationthe solvent is concentrated

Sources & evidence

ORD record
ord-f6032d7236f242c482d52646b1a16cfb
Source dataset
uspto-grants-1994_10
Patent number
US05356904

Reaction notes

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