反应详情

To 2.7 g of ethyl 3-acetylamino-8-methyl-3,4-dihydrocarbostyril-3-carboxylate was added 60 ml of 20%-hydrochloric acid, then the mixture was refluxed by heating for 2 hours. The solvent was removed by evaporation, then water was removed by azetropic distillation with ethanol. The residue thus obtained was recrystallized from methanol-diethyl ether to obtain 1.74 g of 3-amino-8-methyl-3,4-dihydrocarbostyril hydrochloride. Colorless flake-like crystals. Melting point: Over 300° C.

1. temperaturethe mixture was refluxed
2. temperatureby heating for 2 hours
3. customThe solvent was removed by evaporation
4. customwater was removed by azetropic distillation with ethanol
5. customThe residue thus obtained
6. customwas recrystallized from methanol-diethyl ether