Hydrochloric Acid → HCID 14627260, compound

HRID 1708364Notes

Reaction equation

HRID 1708364 reaction equation
C([NH:4][C:5]1(C(OCC)=O)[CH2:14][C:13]2[C:8](=[C:9]([CH3:15])[CH:10]=[CH:11][CH:12]=2)[NH:7][C:6]1=[O:16])(=O)C.[ClH:22]>>[ClH:22].[NH2:4][CH:5]1[CH2:14][C:13]2[C:8](=[C:9]([CH3:15])[CH:10]=[CH:11][CH:12]=2)[NH:7][C:6]1=[O:16]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 14627258HCID 14627258, compound

Product 1

HCID 14627260HCID 14627260, compound

Procedure

To 2.7 g of ethyl 3-acetylamino-8-methyl-3,4-dihydrocarbostyril-3-carboxylate was added 60 ml of 20%-hydrochloric acid, then the mixture was refluxed by heating for 2 hours. The solvent was removed by evaporation, then water was removed by azetropic distillation with ethanol. The residue thus obtained was recrystallized from methanol-diethyl ether to obtain 1.74 g of 3-amino-8-methyl-3,4-dihydrocarbostyril hydrochloride. Colorless flake-like crystals. Melting point: Over 300° C.

Workup

  1. temperaturethe mixture was refluxed
  2. temperatureby heating for 2 hours
  3. customThe solvent was removed by evaporation
  4. customwater was removed by azetropic distillation with ethanol
  5. customThe residue thus obtained
  6. customwas recrystallized from methanol-diethyl ether

Sources & evidence

ORD record
ord-1524071431cc4503975ddcac3cd3b31e
Source dataset
uspto-grants-1994_10
Patent number
US05358949

Reaction notes

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