Hydrochloric Acid → HCID 18958780, compound

HRID 1708372Notes

Reaction equation

HRID 1708372 reaction equation
C([NH:4][C:5]1[C:14]([CH3:15])=[C:13]2[C:8]([CH:9]=[CH:10][C:11](=[O:16])[NH:12]2)=[CH:7][CH:6]=1)(=O)C.[ClH:17]>>[ClH:17].[NH2:4][C:5]1[C:14]([CH3:15])=[C:13]2[C:8]([CH:9]=[CH:10][C:11](=[O:16])[NH:12]2)=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 14627670HCID 14627670, compound

Product 1

HCID 18958780HCID 18958780, compound

Conditions

Temperature
5570 °C

Procedure

To 5 g of 7-acetylamino-8-methylcarbostyril was added 60 ml of 20% hydrochloric acid, and the mixture was heated at 11020 to 120° C. on an oil bath with stirring. After heating for 4 hours, the solvent was removed by evaporation under pressure, then the residue obtained was washed with hot-methanol, dried, next recrystallized from methanol-water to obtain 5.25 g of 7-amino-8-methylcarbostyril hydrochloride. Light yellow needle-like crystals. Melting point: 290°-293° C. (decomposed).

Workup

  1. temperatureAfter heating for 4 hours
  2. customthe solvent was removed by evaporation under pressure
  3. customthe residue obtained
  4. washwas washed with hot-methanol
  5. customdried
  6. customnext recrystallized from methanol-water

Sources & evidence

ORD record
ord-b4ea2d612bfd4f9ca3e10b68a79c846f
Source dataset
uspto-grants-1994_10
Patent number
US05358949

Reaction notes

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