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HRID1708387

反应详情

EQUATION

反应方程式

HRID 1708387 的结构方程式

REACTANTS

反应物

2
结构：CN(CCCl)CCCl.Cl
HCID5935

Nitrogen mustard hydrochloride

C5H12Cl3N

结构：Nc1cc([N+](=O)[O-])ccc1Br
HCID82607

2-Bromo-5-nitroaniline

C6H5BrN2O2

PRODUCTS

生成物

1
结构：CN1CCN(c2cc([N+](=O)[O-])ccc2Br)CC1
HCID22414589

未命名化合物

收率 26.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Clc1ccccc1
溶剂HCID7964

Chlorobenzene

C6H5Cl

PROCEDURE

实验过程

A suspension of 2-bromo-5-nitrobenzenamine (26.0 g) and 2-chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride (23.0 g) in chlorobenzene (150 ml) was treated according to the method of Intermediate 56. Purification by FCC eluting with System A (300:8:1 gradient to 200:8:1) gave the title compound as a brown solid (9.498 g) m.p. 100°-103° C.

WORKUP

后处理

  1. additionwas treated
  2. customPurification by FCC
  3. washeluting with System A (300:8:1 gradient to 200:8:1)