HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitrogen mustard hydrochloride → 1-(2-Bromo-5-nitrophenyl)-4-methylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitrogen mustard hydrochloride | HCID 5935 | — |
| Reactant | 2-Bromo-5-nitroaniline | HCID 82607 | — |
| Solvent | Chlorobenzene | HCID 7964 | — |
| Product | 1-(2-Bromo-5-nitrophenyl)-4-methylpiperazine | HCID 22414589 | 26.5% |
Reaction Steps
A suspension of 2-bromo-5-nitrobenzenamine (26.0 g) and 2-chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride (23.0 g) in chlorobenzene (150 ml) was treated according to the method of Intermediate 56. Purification by FCC eluting with System A (300:8:1 gradient to 200:8:1) gave the title compound as a brown solid (9.498 g) m.p. 100°-103° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05358948 |
| Source dataset | uspto-grants-1994_10 |
| ORD ID | ord-12a072e796484ceaaf8c4e13ea56113e |
| Source note | uspto-grants-1994_10 |