Hydrochloric Acid → HCID 18958846, compound

Participants

Reaction Conditions

Reaction Steps

2.5 g of 2- {[4 - {[7 -n-propyl-5-methyl- 3-oxo-2-(ethoxycarbonylmethyl)-2,3-dihydro-1,2,4-triazolo[4,3-c]-pyrimidin- 8-Yl]methyl}phenyl]aminocarbonyl}benzenesulphonic acid, prepared in Example 34, are dissolved in 30 ml of water containing 1 g of sodium hydroxide. The mixture is heated to 60° C. for 2 hours, cooled and acidified with hydrochloric acid to give 2 g of 2-{[4-{[7-n-propyl-5-methyl-3-oxo-2-(carboxymethyl)-2,3-dihydro-1,2,4-triazolo[4,3-c]pyrimidin-8-yl]methyl}phenyl]-aminocarbonyl}benzenesulphonic acid in the form of crystals of melting point 296°-300° C.

Provenance & Evidence