Hydrochloric Acid → HCID 18958846, compound

HRID 1708404Notes

Reaction equation

[CH2:1]([C:4]1[N:9]=[C:8]([CH3:10])[N:7]2[C:11](=[O:20])[N:12]([CH2:14][C:15]([O:17]CC)=[O:16])[N:13]=[C:6]2[C:5]=1[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[S:37]([OH:40])(=[O:39])=[O:38])=[O:30])=[CH:24][CH:23]=1)[CH2:2][CH3:3].Cl>O.[OH-].[Na+]>[CH2:1]([C:4]1[N:9]=[C:8]([CH3:10])[N:7]2[C:11](=[O:20])[N:12]([CH2:14][C:15]([OH:17])=[O:16])[N:13]=[C:6]2[C:5]=1[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[S:37]([OH:40])(=[O:38])=[O:39])=[O:30])=[CH:24][CH:23]=1)[CH2:2][CH3:3]

Participants

Conditions

Temperature: 60 °C

Procedure

2.5 g of 2- {[4 - {[7 -n-propyl-5-methyl- 3-oxo-2-(ethoxycarbonylmethyl)-2,3-dihydro-1,2,4-triazolo[4,3-c]-pyrimidin- 8-Yl]methyl}phenyl]aminocarbonyl}benzenesulphonic acid, prepared in Example 34, are dissolved in 30 ml of water containing 1 g of sodium hydroxide. The mixture is heated to 60° C. for 2 hours, cooled and acidified with hydrochloric acid to give 2 g of 2-{[4-{[7-n-propyl-5-methyl-3-oxo-2-(carboxymethyl)-2,3-dihydro-1,2,4-triazolo[4,3-c]pyrimidin-8-yl]methyl}phenyl]-aminocarbonyl}benzenesulphonic acid in the form of crystals of melting point 296°-300° C.

Workup

temperaturecooled

Sources & evidence

ORD record: ord-3587e7b3deb44524be296e4bb4ef55a5
Source dataset: uspto-grants-1994_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05358950

Reaction notes

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