HCID 10474143, compound → HCID 18958849, compound

HRID 1708408Notes

Reaction equation

HRID 1708408 reaction equation
[CH2:1]([C:4]1[N:9]=[C:8]([CH3:10])[N:7]2[CH:11]=[N:12][N:13]=[C:6]2[C:5]=1[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[C:27]#[N:28])=[CH:17][CH:16]=1)[CH2:2][CH3:3]>C(O)=O>[CH2:1]([C:4]1[N:9]=[C:8]([CH3:10])[N:13]2[N:12]=[CH:11][N:7]=[C:6]2[C:5]=1[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[C:27]#[N:28])=[CH:17][CH:16]=1)[CH2:2][CH3:3]

Participants

3

Reactant 1

HCID 10474143HCID 10474143, compound

Product 1

HCID 18958849HCID 18958849, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

10 g of 7-n-propyl-5-methyl-8-[(2'-cyano-4-biphenylyl)methyl]-1,2,4-triazolo[4,3-c]pyrimidine, prepared in Example 69, are heated to reflux for 4 hours in 150 ml of formic acid. The mixture is evaporated to dryness under vacuum, and the residue, taken up with ether and pentane, crystallises to give 7.5 g of 7-n-propyl-5-methyl-8-[(2'-cyano-4-biphenylyl)methyl]-1,2,4-triazolo[1,5-c]pyrimidine in the form of crystals of melting point 112° C.

Workup

  1. temperatureare heated
  2. customThe mixture is evaporated to dryness under vacuum
  3. customcrystallises

Sources & evidence

ORD record
ord-b1503894df3c4723b0ab1dca2a5a2d29
Source dataset
uspto-grants-1994_10
Patent number
US05358950

Reaction notes

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