Ethyl orthoformate → HCID 178440122, compound

HRID 1708409Notes

Reaction equation

HRID 1708409 reaction equation
[CH2:1]([C:4]1[N:9]=[C:8]([CH3:10])[N:7]=[C:6]([NH:11][NH2:12])[C:5]=1[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26]2[NH:30][N:29]=[N:28][N:27]=2)=[CH:16][CH:15]=1)[CH2:2][CH3:3].[CH:31](OCC)(OCC)OCC>>[CH2:1]([C:4]1[N:9]=[C:8]([CH3:10])[N:7]2[CH:31]=[N:12][N:11]=[C:6]2[C:5]=1[CH2:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26]2[NH:30][N:29]=[N:28][N:27]=2)=[CH:18][CH:19]=1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 31214Ethyl orthoformateHCID 178440128HCID 178440128, compound

Product 1

HCID 178440122HCID 178440122, compound

Procedure

4.8 g of 6-n-propyl-2-methyl-4-hydrazino-5-{[2'(5-tetrazolyl)-4-biphenylyl]methyl}pyrimidine, prepared in Example 67, are heated to reflux for 4 hours in 40 ml of triethyl orthoformate. The mixture is evaporated under vacuum and the residue is crystallised in an ethyl acetate/isopropyl ether mixture to give 1 g of 7-n-propyl-5-methyl-8-{[2'-(5-tetrazolyl)-4biphenylyl]methyl}-1,2,4-triazolo[4,3-c]pyrimidine in the form of crystals of melting point 182°-184° C.

Workup

  1. temperatureare heated
  2. customThe mixture is evaporated under vacuum
  3. customthe residue is crystallised in an ethyl acetate/isopropyl ether mixture

Sources & evidence

ORD record
ord-ee1f70c1561c4cfbb133b8873247035f
Source dataset
uspto-grants-1994_10
Patent number
US05358950

Reaction notes

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