Ethyl orthoformate → HCID 178440122, compound

Participants

Reaction Steps

4.8 g of 6-n-propyl-2-methyl-4-hydrazino-5-{[2'(5-tetrazolyl)-4-biphenylyl]methyl}pyrimidine, prepared in Example 67, are heated to reflux for 4 hours in 40 ml of triethyl orthoformate. The mixture is evaporated under vacuum and the residue is crystallised in an ethyl acetate/isopropyl ether mixture to give 1 g of 7-n-propyl-5-methyl-8-{[2'-(5-tetrazolyl)-4biphenylyl]methyl}-1,2,4-triazolo[4,3-c]pyrimidine in the form of crystals of melting point 182°-184° C.

Provenance & Evidence