Methyl iodide → HCID 178440259, compound

HRID 1708412Notes

Reaction equation

HRID 1708412 reaction equation
[CH2:1]([C:4]1[N:9]=[C:8]([SH:10])[N:7]=[C:6]([OH:11])[C:5]=1[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[C:25]#[N:26])=[CH:15][CH:14]=1)[CH2:2][CH3:3].[OH-].[K+].[CH3:29]I>CO>[CH2:1]([C:4]1[N:9]=[C:8]([S:10][CH3:29])[N:7]=[C:6]([OH:11])[C:5]=1[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[C:25]#[N:26])=[CH:15][CH:14]=1)[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 178440260HCID 178440260, compound

Product 1

HCID 178440259HCID 178440259, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

26 g of 6-n-propyl-2-mercapto-4-hydroxy-5[(2'-cyano-4-biphenylyl)methyl]pyrimidine, prepared in Example 100, are stirred for 15 minutes in a solution of 5 g of potassium hydroxide in 100 ml of methanol. 6 ml of methyl iodide are added to the mixture, which is then stirred for 4 hours at room temperature. The crystals formed are drained, washed with water and then with ether and dried to give 23 g of 6-n-propyl-2-methylthio-4-hydroxy-5-[(2'-cyano-4-biphenylyl)methyl]pyrimidine in the form of crystals of melting point 218° C.

Workup

  1. customThe crystals formed
  2. washwashed with water
  3. dry with materialwith ether and dried

Sources & evidence

ORD record
ord-daab52676ead41fcb58e0f1fc4f640aa
Source dataset
uspto-grants-1994_10
Patent number
US05358950

Reaction notes

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