Methyl iodide → HCID 178440259, compound

Participants

Reaction Steps

26 g of 6-n-propyl-2-mercapto-4-hydroxy-5[(2'-cyano-4-biphenylyl)methyl]pyrimidine, prepared in Example 100, are stirred for 15 minutes in a solution of 5 g of potassium hydroxide in 100 ml of methanol. 6 ml of methyl iodide are added to the mixture, which is then stirred for 4 hours at room temperature. The crystals formed are drained, washed with water and then with ether and dried to give 23 g of 6-n-propyl-2-methylthio-4-hydroxy-5-[(2'-cyano-4-biphenylyl)methyl]pyrimidine in the form of crystals of melting point 218° C.

Provenance & Evidence