HCID 18958851, compound → HCID 18958839, compound

HRID 1708424Notes

Reaction equation

HRID 1708424 reaction equation
[CH2:1]([C:4]1[N:9]=[C:8]([CH3:10])[N:7]2[C:11](=[O:14])[NH:12][N:13]=[C:6]2[CH:5]=1)[CH2:2][CH3:3]>C(O)(=O)C>[CH2:1]([C:4]1[N:9]=[C:8]([CH3:10])[N:13]2[NH:12][C:11](=[O:14])[N:7]=[C:6]2[CH:5]=1)[CH2:2][CH3:3]

Participants

3

Reactant 1

HCID 18958851HCID 18958851, compound

Product 1

HCID 18958839HCID 18958839, compoundYield 77.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 15.5 g of 7-n-propyl-5-methyl-1,2,4-triazolo[4,3-c]pyrimidin-3(2H)-one, prepared in Example 192, in 100 ml of acetic acid is heated to reflux for 20 h. The reaction mixture is then evaporated under vacuum, and the residue obtained crystallises in ethyl ether. The drained crystals are washed with ethyl ether and dried. 12 g of 7-n-propyl-5-methyl-1,2,4-triazolo[1,5-c]pyrimidin-2(3H)-one are obtained in the form of crystals of melting point 173° C.

Workup

  1. temperatureis heated
  2. temperatureto reflux for 20 h
  3. customThe reaction mixture is then evaporated under vacuum
  4. customthe residue obtained
  5. customcrystallises in ethyl ether
  6. washThe drained crystals are washed with ethyl ether
  7. customdried

Sources & evidence

ORD record
ord-17a87f3a74d64a159eb8b42ffb32c0db
Source dataset
uspto-grants-1994_10
Patent number
US05358950

Reaction notes

Loading…