Triethylamine → 5-amino-1H-pyrazole-1-carboxamide

HRID 1708434Notes

Reaction equation

HRID 1708434 reaction equation
[C:1]([CH:3]=[CH:4][NH:5][NH:6][C:7]([NH2:9])=[O:8])#[N:2].C(N(CC)CC)C>C(O)C>[NH2:2][C:1]1[N:6]([C:7]([NH2:9])=[O:8])[N:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 73473493HCID 73473493, compound

Product 1

HCID 2966355-amino-1H-pyrazole-1-carboxamideYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 5.0 g of the product of Example 13 in 50 ml of ethyl alcohol containing 3.0 ml of triethylamine is heated at reflux for 4 hours then concentrated in vacuo to a residue which is stirred with cold water. The resulting solid is filtered, washed with additional cold water and dried to give 4.0 g of the desired product as a yellow crystalline solid. M+H=127.

Workup

  1. temperatureat reflux for 4 hours
  2. concentrationthen concentrated in vacuo to a residue which
  3. filtrationThe resulting solid is filtered
  4. washwashed with additional cold water
  5. customdried

Sources & evidence

ORD record
ord-b430d70547d54932b594d394fd92d52e
Source dataset
uspto-grants-1994_10
Patent number
US05358947

Reaction notes

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