Trimethyl orthovalerate → HCID 178441879, compound

HRID 1708435Notes

Reaction equation

HRID 1708435 reaction equation
[NH2:1][C:2]1[N:6]([C:7]([NH2:9])=[O:8])[N:5]=[CH:4][CH:3]=1.CO[C:12](OC)(OC)[CH2:13][CH2:14][CH2:15][CH3:16]>>[CH2:13]([C:12]1[NH:1][C:2]2[N:6]([N:5]=[CH:4][CH:3]=2)[C:7](=[O:8])[N:9]=1)[CH2:14][CH2:15][CH3:16]

Participants

3

Reactant 2

HCID 83755Trimethyl orthovalerateHCID 2966355-amino-1H-pyrazole-1-carboxamide

Product 1

HCID 178441879HCID 178441879, compound

Procedure

A solution of 3.0 g of the product of Example 14 in 10 ml of trimethylorthovalerate is heated at 130° C. for 1 hour. The reaction mixture is cooled to room temperature and diluted with hexanes. The resulting solid is collected, washed with hexanes and dried to give 2.0 g of the desired product as a solid. M+H=193.

Workup

  1. customThe resulting solid is collected
  2. washwashed with hexanes
  3. customdried

Sources & evidence

ORD record
ord-6a518304d1af4d4d97592eab8d2288d4
Source dataset
uspto-grants-1994_10
Patent number
US05358947

Reaction notes

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