反应详情

温度

0 °C

To a solution of 0.25 g of 2-butyl-1,4-dihydro-4-oxo-6-quinazolinecarboxaldehyde in 10 ml of dry tetrahydrofuran, cooled to 0° C., is added 1.63 ml of 2.0M ethyl magnesium bromide in tetrahydrofuran. The reaction mixture is stirred for 30 minutes at 0° C. and quenched with 20 ml of saturated ammonium chloride solution and 20 ml of water. The reaction mixture is extracted with 9:1 chloroform-methanol, dried over magnesium sulfate, filtered and evaporated in vacuo to give 0.26 g of the desired product. CI MASS SPEC 261(MH+).

1. customquenched with 20 ml of saturated ammonium chloride solution and 20 ml of water
2. extractionThe reaction mixture is extracted with 9:1 chloroform-methanol
3. dry with materialdried over magnesium sulfate
4. filtrationfiltered
5. customevaporated in vacuo