反应详情

A solution of the above ester and 1N sodium hydroxide (3 ml) in methanol (12 ml) was refluxed at 50° C. for 72 h and then concentrated in vacuo. To the residue was added water (5 ml) and 10% citric acid to pH 3, and the resulting solid was filtered crystallized from methanol to provide 500 mg of 2-cyclohexyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic acid.

1. concentrationconcentrated in vacuo
2. additionTo the residue was added water (5 ml) and 10% citric acid to pH 3
3. filtrationthe resulting solid was filtered
4. customcrystallized from methanol