HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-cyclohexyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Cyclohexyl-2-[4-(quinolin-2-yl-methoxy)phenyl]acetic acid methyl ester | HCID 14674836 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-cyclohexyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic Acid | HCID 11199705 | — |
Reaction Steps
A solution of the above ester and 1N sodium hydroxide (3 ml) in methanol (12 ml) was refluxed at 50° C. for 72 h and then concentrated in vacuo. To the residue was added water (5 ml) and 10% citric acid to pH 3, and the resulting solid was filtered crystallized from methanol to provide 500 mg of 2-cyclohexyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05358955 |
| Source dataset | uspto-grants-1994_10 |
| ORD ID | ord-ee5dde2728bc439695c026a75e7239f2 |
| Source note | uspto-grants-1994_10 |